Cortexa research tool·genomics·eve

EVE Get Variant Score

Get EVE (Evolutionary Variant Effect) pathogenicity score for a variant. EVE uses unsupervised deep learning on evolutionary data. Scores: 0-1 where >0.5 is likely pathogenic. Accessed via Ensembl VEP API.

Livelast probed 2026-04-30 23:07Z· 127msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 127ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "alt": {
      "description": "Alternate allele",
      "type": "string"
    },
    "chrom": {
      "description": "Chromosome (1-22, X, Y). Use with pos, ref, alt instead of variant.",
      "type": "string"
    },
    "pos": {
      "description": "Genomic position (GRCh38)",
      "type": "integer"
    },
    "ref": {
      "description": "Reference allele",
      "type": "string"
    },
    "species": {
      "default": "human",
      "description": "Species (default: human)",
      "type": "string"
    },
    "variant": {
      "description": "Variant in HGVS format (e.g., 'ENST00000269305.4:c.100G>A', 'NM_000546.5:c.215C>G')",
      "type": "string"
    }
  },
  "type": "object"
}

Examples (1)

Default EVE Get Variant Score call

public-safeinput

{
  "pos": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_EVE_get_variant_score
Tool name: EVE_get_variant_score
Added: 2026-04-30 22:47Z
Tags: tooluniverse

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