Cortexa research tool·genomics·genome_nexus

GenomeNexus Get Cancer Hotspots

Get cancer mutation hotspot annotations from Genome Nexus (MSK) for a specific genomic variant. Cancer hotspots are recurrently mutated residues in cancer, curated by the Chang et al. study. Returns hotspot residue, tumor count, hotspot type (single residue or 3D cluster), and the gene symbol. Use this to check if a variant falls in a known cancer hotspot. Input is a GRCh37/hg19 HGVS genomic variant. Example: '7:g.140453136A>T' (BRAF V600E) returns V600 hotspot with 897 tumors.

Livelast probed 2026-04-30 23:07Z· 7183msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 7183ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "hgvsg": {
      "description": "Genomic variant in HGVS notation using GRCh37/hg19 coordinates. Format: 'chr:g.posRef>Alt'. Examples: '7:g.140453136A>T' (BRAF V600E), '17:g.7577120C>T' (TP53 R273H).",
      "type": "string"
    }
  },
  "required": [
    "hgvsg"
  ],
  "type": "object"
}

Examples (1)

Default GenomeNexus Get Cancer Hotspots call

public-safeinput

{
  "hgvsg": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_GenomeNexus_get_cancer_hotspots
Tool name: GenomeNexus_get_cancer_hotspots
Added: 2026-04-30 22:47Z
Tags: tooluniverse

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