Cortexa research tool·genomics·iedb_prediction

IEDB Predict Mhci Binding

Predict MHC class I peptide binding using NetMHCpan via the IEDB Analysis Resource API. Given a protein sequence and HLA allele, predicts which peptides will bind and be presented on the cell surface. Returns peptides ranked by percentile rank (lower = stronger binding). Essential for vaccine design, neoantigen prediction, and epitope mapping. Supports human HLA-A/B/C and mouse H-2 alleles.

Livelast probed 2026-04-30 23:07Z· 116msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 116ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "allele": {
      "default": "HLA-A*02:01",
      "description": "MHC allele name. Human: 'HLA-A*02:01', 'HLA-B*07:02'. Mouse: 'H-2-Kd', 'H-2-Db'. Default: HLA-A*02:01",
      "type": "string"
    },
    "length": {
      "default": 9,
      "description": "Peptide length (8-14 for MHC-I, typically 9)",
      "type": "integer"
    },
    "method": {
      "default": "netmhcpan_el",
      "description": "Prediction method. 'netmhcpan_el' (recommended, eluted ligand), 'netmhcpan_ba' (binding affinity), 'ann', 'smm'",
      "type": "string"
    },
    "sequence": {
      "description": "Protein sequence (amino acid letters, e.g., 'TYQRTRALVFQRTRALKMFAL'). Multiple peptides can be concatenated.",
      "type": "string"
    }
  },
  "required": [
    "sequence"
  ],
  "type": "object"
}

Examples (1)

Default IEDB Predict Mhci Binding call

public-safeinput

{
  "length": 1,
  "sequence": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_IEDB_predict_mhci_binding
Tool name: IEDB_predict_mhci_binding
Added: 2026-04-30 22:47Z
Tags: tooluniverse

IEDB Predict Mhci Binding

Livelast probed 2026-04-30 23:07Z· 116msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "allele": { "default": "HLA-A*02:01", "description": "MHC allele name. Human: 'HLA-A*02:01', 'HLA-B*07:02'. Mouse: 'H-2-Kd', 'H-2-Db'. Default: HLA-A*02:01", "type": "string" }, "length": { "default": 9, "description": "Peptide length (8-14 for MHC-I, typically 9)", "type": "integer" }, "method": { "default": "netmhcpan_el", "description": "Prediction method. 'netmhcpan_el' (recommended, eluted ligand), 'netmhcpan_ba' (binding affinity), 'ann', 'smm'", "type": "string" }, "sequence": { "description": "Protein sequence (amino acid letters, e.g., 'TYQRTRALVFQRTRALKMFAL'). Multiple peptides can be concatenated.", "type": "string" } }, "required": [ "sequence" ], "type": "object" }