InterVar Classify Variant

Classify a germline variant using ACMG/AMP 2015 standards (InterVar). Returns the clinical significance category — Pathogenic, Likely Pathogenic, Uncertain Significance, Likely Benign, or Benign — plus the activation status of all 28 evidence criteria (PVS1, PS1-PS4, PM1-PM6, PP1-PP5, BA1, BP1-BP7, BS1-BS4). Input requires genomic coordinates in hg19 or hg38. No API key needed. Example: BRCA1 c.5266dupC (chr17:41245466 G>A in hg19) is Likely Pathogenic with PM2+PP3+PP5.