PDBePISA Get Interfaces

Analyze protein-protein and protein-ligand interfaces in a crystal structure using PDBePISA. Returns interface area, solvation energy, p-value, hydrogen bonds, salt bridges, disulfide bonds, and per-molecule contributions for each interface. Use after retrieving a PDB structure from RCSB/PDBe tools to assess biological relevance of crystal contacts. Low p-value (<0.5) and negative solvation energy suggest biologically relevant interfaces.