Cortexa research tool·structure·protvar

ProtVar Get Function

Get functional annotations at a specific amino acid position from ProtVar. Returns annotated UniProt features overlapping that position (domains, active sites, binding sites, PTMs), the protein's function description, and structural context. Use to understand the biological importance of a variant site before interpreting pathogenicity scores. Example: P04637 position 175 returns DNA-binding domain overlap and TP53 tumor suppressor function.

Livelast probed 2026-04-30 23:07Z· 107msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 107ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "accession": {
      "description": "UniProt accession (e.g. 'P04637' for TP53).",
      "type": "string"
    },
    "position": {
      "description": "Amino acid position in the protein (1-based).",
      "type": "integer"
    },
    "variant_aa": {
      "description": "Single-letter code for the variant amino acid (e.g. 'H' for histidine). Optional but recommended.",
      "type": "string"
    }
  },
  "required": [
    "accession",
    "position"
  ],
  "type": "object"
}

Examples (1)

Default ProtVar Get Function call

public-safeinput

{
  "accession": "P38398",
  "position": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_ProtVar_get_function
Tool name: ProtVar_get_function
Added: 2026-04-30 22:47Z
Tags: tooluniverse

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