Cortexa research tool·genomics·protvar

ProtVar Map Variant

Map a human protein variant to genomic coordinates and get pathogenicity predictions (AlphaMissense, EVE, ESM, conservation). Accepts three input formats: (1) protein 'ACCESSION CHANGE' e.g. 'P04637 R175H'; (2) dbSNP rsID e.g. 'rs1799966'; (3) VCF-style genomic 'chr17 43057065 . T G'. Returns isoform mappings, consequence type, and variant effect scores.

Livelast probed 2026-04-30 23:07Z· 108msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 108ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "variant": {
      "description": "Variant identifier in one of three formats: (1) 'UniProtAccession SingleLetterChange' e.g. 'P04637 R175H' (TP53 R175H); (2) dbSNP rsID e.g. 'rs1799966'; (3) VCF genomic 'chr17 43057065 . REF ALT'. Note: colon-separated 'chr:pos:ref:alt' is auto-converted to VCF format.",
      "type": "string"
    }
  },
  "required": [
    "variant"
  ],
  "type": "object"
}

Examples (1)

Default ProtVar Map Variant call

public-safeinput

{
  "variant": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_ProtVar_map_variant
Tool name: ProtVar_map_variant
Added: 2026-04-30 22:47Z
Tags: tooluniverse

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