Cortexa research tool·genomics·ensembl

Ensembl Get Homology

Get homology (orthologues and paralogues) for a gene by symbol across species. Returns evolutionary relationships with gene IDs, protein IDs, chromosomal locations, and homology types (1-to-1, 1-to-many, etc). Essential for comparative genomics studies.

Livelast probed 2026-05-01 01:00Z· 673msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 673ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "aligned": {
      "default": false,
      "description": "Return aligned sequences",
      "type": "boolean"
    },
    "sequence": {
      "default": "none",
      "description": "Include sequences in response",
      "enum": [
        "cdna",
        "protein",
        "none"
      ],
      "type": "string"
    },
    "species": {
      "description": "Source species (e.g., 'human', 'homo_sapiens')",
      "type": "string"
    },
    "symbol": {
      "description": "Gene symbol (e.g., 'BRCA2', 'TP53')",
      "type": "string"
    },
    "target_species": {
      "description": "Target species to find homologues in (optional, e.g., 'mouse', 'mus_musculus'). Leave empty to search all species.",
      "type": "string"
    },
    "target_taxon": {
      "description": "Target taxonomic group (optional, e.g., 'Mammalia', 'Primates')",
      "type": "string"
    },
    "type": {
      "default": "all",
      "description": "Homology type: 'orthologues' (different species), 'paralogues' (same species), 'all' (both)",
      "enum": [
        "orthologues",
        "paralogues",
        "all"
      ],
      "type": "string"
    }
  },
  "required": [
    "species",
    "symbol"
  ],
  "type": "object"
}

Examples (1)

Default Ensembl Get Homology call

public-safeinput

{
  "aligned": false,
  "species": "",
  "symbol": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_ensembl_get_homology
Tool name: ensembl_get_homology
Added: 2026-05-01 00:58Z
Tags: tooluniverse

Ensembl Get Homology

Livelast probed 2026-05-01 01:00Z· 673msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "aligned": { "default": false, "description": "Return aligned sequences", "type": "boolean" }, "sequence": { "default": "none", "description": "Include sequences in response", "enum": [ "cdna", "protein", "none" ], "type": "string" }, "species": { "description": "Source species (e.g., 'human', 'homo_sapiens')", "type": "string" }, "symbol": { "description": "Gene symbol (e.g., 'BRCA2', 'TP53')", "type": "string" }, "target_species": { "description": "Target species to find homologues in (optional, e.g., 'mouse', 'mus_musculus'). Leave empty to search all species.", "type": "string" }, "target_taxon": { "description": "Target taxonomic group (optional, e.g., 'Mammalia', 'Primates')", "type": "string" }, "type": { "default": "all", "description": "Homology type: 'orthologues' (different species), 'paralogues' (same species), 'all' (both)", "enum": [ "orthologues", "paralogues", "all" ], "type": "string" } }, "required": [ "species", "symbol" ], "type": "object" }