Cortexa research tool·structure·bindingdb

BindingDB Get Ligands By Uniprot

Get binding affinity data (Ki, IC50, Kd) for a single protein by UniProt ID. Returns SMILES structures and measured affinities from BindingDB. Essential for drug discovery target analysis. Example: P00533 (EGFR) returns known inhibitors with binding constants.

Livelast probed 2026-04-30 23:07Z· 105msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 105ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "affinity_cutoff": {
      "default": 10000,
      "description": "Maximum affinity in nM (default: 10000)",
      "type": "integer"
    },
    "uniprot_id": {
      "description": "UniProt accession ID (e.g., P00533 for EGFR)",
      "type": "string"
    }
  },
  "required": [
    "uniprot_id"
  ],
  "type": "object"
}

Examples (1)

Default BindingDB Get Ligands By Uniprot call

public-safeinput

{
  "affinity_cutoff": 1,
  "uniprot_id": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_BindingDB_get_ligands_by_uniprot
Tool name: BindingDB_get_ligands_by_uniprot
Added: 2026-04-30 22:47Z
Tags: tooluniverse

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