Cortexa research tool·biomedical·cosmic

COSMIC Get Mutations By Gene

Get all somatic mutations for a specific gene from COSMIC database. Returns comprehensive mutation data for a gene symbol including CDS changes, amino acid changes, cancer types, and genomic positions. Useful for exploring the mutational landscape of cancer genes like BRAF, TP53, EGFR, KRAS, etc.

Livelast probed 2026-05-01 01:00Z· 106msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 106ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "gene": {
      "description": "Gene symbol (e.g., BRAF, TP53, EGFR, KRAS, PIK3CA). Alias: gene_name also accepted.",
      "type": "string"
    },
    "gene_name": {
      "description": "Alias for gene parameter. Gene symbol (e.g., FLT3, BRAF, TP53).",
      "type": "string"
    },
    "genome_build": {
      "default": 37,
      "description": "Genome build version: 37 (GRCh37/hg19) or 38 (GRCh38/hg38). Default: 37",
      "enum": [
        37,
        38
      ],
      "type": "integer"
    },
    "max_results": {
      "default": 100,
      "description": "Maximum number of mutations to return (default: 100, max: 500)",
      "maximum": 500,
      "minimum": 1,
      "type": "integer"
    },
    "operation": {
      "const": "get_by_gene",
      "description": "Operation type (fixed: get_by_gene)",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default COSMIC Get Mutations By Gene call

public-safeinput

{
  "gene": "BRCA1",
  "gene_name": "BRCA1",
  "genome_build": 1,
  "max_results": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_COSMIC_get_mutations_by_gene
Tool name: COSMIC_get_mutations_by_gene
Added: 2026-05-01 00:58Z
Tags: tooluniverse

COSMIC Get Mutations By Gene

Livelast probed 2026-05-01 01:00Z· 106msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "gene": { "description": "Gene symbol (e.g., BRAF, TP53, EGFR, KRAS, PIK3CA). Alias: gene_name also accepted.", "type": "string" }, "gene_name": { "description": "Alias for gene parameter. Gene symbol (e.g., FLT3, BRAF, TP53).", "type": "string" }, "genome_build": { "default": 37, "description": "Genome build version: 37 (GRCh37/hg19) or 38 (GRCh38/hg38). Default: 37", "enum": [ 37, 38 ], "type": "integer" }, "max_results": { "default": 100, "description": "Maximum number of mutations to return (default: 100, max: 500)", "maximum": 500, "minimum": 1, "type": "integer" }, "operation": { "const": "get_by_gene", "description": "Operation type (fixed: get_by_gene)", "type": "string" } }, "required": [], "type": "object" }