Cortexa research tool·biomedical·cosmic

COSMIC Search Mutations

Search COSMIC database for somatic mutations in cancer. COSMIC is the world's largest expert-curated database of somatic mutations in human cancer. Search by gene name, mutation ID, or mutation description. Returns mutation IDs, gene names, CDS changes, and amino acid changes. No authentication required.

Livelast probed 2026-05-01 01:00Z· 102msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 102ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "genome_build": {
      "default": 37,
      "description": "Genome build version: 37 (GRCh37/hg19) or 38 (GRCh38/hg38). Default: 37",
      "enum": [
        37,
        38
      ],
      "type": "integer"
    },
    "max_results": {
      "default": 20,
      "description": "Maximum number of results to return (default: 20, max: 500)",
      "maximum": 500,
      "minimum": 1,
      "type": "integer"
    },
    "operation": {
      "const": "search",
      "description": "Operation type (fixed: search)",
      "type": "string"
    },
    "query": {
      "description": "Alias for terms. Search query - gene name, mutation, or COSMIC ID.",
      "type": "string"
    },
    "terms": {
      "description": "Search query - gene name (e.g., BRAF), mutation (e.g., V600E), or mutation ID (e.g., COSM476). Aliases: query or gene also accepted.",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default COSMIC Search Mutations call

public-safeinput

{
  "genome_build": 1,
  "max_results": 1,
  "query": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_COSMIC_search_mutations
Tool name: COSMIC_search_mutations
Added: 2026-05-01 00:58Z
Tags: tooluniverse

COSMIC Search Mutations

Livelast probed 2026-05-01 01:00Z· 102msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "genome_build": { "default": 37, "description": "Genome build version: 37 (GRCh37/hg19) or 38 (GRCh38/hg38). Default: 37", "enum": [ 37, 38 ], "type": "integer" }, "max_results": { "default": 20, "description": "Maximum number of results to return (default: 20, max: 500)", "maximum": 500, "minimum": 1, "type": "integer" }, "operation": { "const": "search", "description": "Operation type (fixed: search)", "type": "string" }, "query": { "description": "Alias for terms. Search query - gene name, mutation, or COSMIC ID.", "type": "string" }, "terms": { "description": "Search query - gene name (e.g., BRAF), mutation (e.g., V600E), or mutation ID (e.g., COSM476). Aliases: query or gene also accepted.", "type": "string" } }, "required": [], "type": "object" }