CancerVar Classify Variant

Overview

Classify a somatic cancer variant using AMP/ASCO/CAP 2017 guidelines (CancerVar). Returns a Tier I–IV assignment: Tier I = Strong Clinical Significance (FDA-approved therapy association), Tier II = Potential Clinical Significance (investigational/preclinical evidence), Tier III = Unknown Clinical Significance, Tier IV = Benign/Likely Benign. Also returns 12 CBP evidence scores and an Oncogenicity Pathogenicity Index (OPAI, 0–1). Input requires genomic coordinates in hg19 or hg38. No API key needed. Example: BRAF V600E (chr7:140453136 A>T hg19) is Tier I (strong) with OPAI=0.99.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

116ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "alt": {
      "description": "Alternate allele (e.g., 'T', 'C').",
      "type": "string"
    },
    "build": {
      "default": "hg19",
      "description": "Genome build. Default: hg19.",
      "enum": [
        "hg19",
        "hg38"
      ],
      "type": "string"
    },
    "chrom": {
      "description": "Chromosome number or name. Can include 'chr' prefix (e.g., '7', 'chr7', 'X').",
      "type": "string"
    },
    "pos": {
      "description": "Genomic position (1-based).",
      "type": "integer"
    },
    "ref": {
      "description": "Reference allele (e.g., 'A', 'G', 'ATCG').",
      "type": "string"
    }
  },
  "required": [
    "chrom",
    "pos",
    "ref",
    "alt"
  ],
  "type": "object"
}

Examples (1)

{
  "alt": "",
  "chrom": "",
  "pos": 1,
  "ref": ""
}

Identifiers

Catalog ID

tu_CancerVar_classify_variant

Tool name

CancerVar_classify_variant

Added

2026-04-30 22:47Z

Tags

tooluniverse