Cortexa research tool·genomics·clinvar

ClinVar Search Variants

Search for variants in ClinVar database by gene name, condition, or variant ID. Returns variant identifiers and basic information. At least one of gene, condition, or variant_id must be provided.

Livelast probed 2026-04-30 23:07Z· 109msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 109ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "clinical_significance": {
      "description": "Filter by clinical significance (e.g., 'Pathogenic', 'Likely pathogenic', 'Benign', 'Uncertain significance', 'VUS'). Applied client-side after retrieval.",
      "type": "string"
    },
    "condition": {
      "description": "Disease or condition name (e.g., 'breast cancer', 'diabetes') At least one of gene, condition, or variant_id must be provided.",
      "type": "string"
    },
    "gene": {
      "description": "Gene name or symbol (e.g., 'BRCA1', 'BRCA2') At least one of gene, condition, or variant_id must be provided.",
      "type": "string"
    },
    "gene_symbol": {
      "description": "Alias for gene. HGNC gene symbol (e.g., \"DPYD\", \"CYP2C19\").",
      "type": [
        "string",
        "null"
      ]
    },
    "limit": {
      "description": "Alias for max_results: maximum number of results to return.",
      "maximum": 100,
      "minimum": 1,
      "type": "integer"
    },
    "max_results": {
      "default": 20,
      "description": "Maximum number of results to return (default: 20). Alias: limit.",
      "maximum": 100,
      "minimum": 1,
      "type": "integer"
    },
    "query": {
      "description": "Alias for condition. Free-text search mapped to condition/disease field.",
      "type": [
        "string",
        "null"
      ]
    },
    "significance": {
      "description": "Alias for clinical_significance (e.g., \"pathogenic\", \"benign\", \"uncertain_significance\").",
      "type": [
        "string",
        "null"
      ]
    },
    "variant_id": {
      "description": "ClinVar variant ID (e.g., '12345') At least one of gene, condition, or variant_id must be provided.",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default ClinVar Search Variants call

public-safeinput

{
  "gene": "BRCA1",
  "limit": 3,
  "max_results": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_ClinVar_search_variants
Tool name: ClinVar_search_variants
Added: 2026-04-30 22:47Z
Tags: tooluniverse

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "clinical_significance": { "description": "Filter by clinical significance (e.g., 'Pathogenic', 'Likely pathogenic', 'Benign', 'Uncertain significance', 'VUS'). Applied client-side after retrieval.", "type": "string" }, "condition": { "description": "Disease or condition name (e.g., 'breast cancer', 'diabetes') At least one of gene, condition, or variant_id must be provided.", "type": "string" }, "gene": { "description": "Gene name or symbol (e.g., 'BRCA1', 'BRCA2') At least one of gene, condition, or variant_id must be provided.", "type": "string" }, "gene_symbol": { "description": "Alias for gene. HGNC gene symbol (e.g., \"DPYD\", \"CYP2C19\").", "type": [ "string", "null" ] }, "limit": { "description": "Alias for max_results: maximum number of results to return.", "maximum": 100, "minimum": 1, "type": "integer" }, "max_results": { "default": 20, "description": "Maximum number of results to return (default: 20). Alias: limit.", "maximum": 100, "minimum": 1, "type": "integer" }, "query": { "description": "Alias for condition. Free-text search mapped to condition/disease field.", "type": [ "string", "null" ] }, "significance": { "description": "Alias for clinical_significance (e.g., \"pathogenic\", \"benign\", \"uncertain_significance\").", "type": [ "string", "null" ] }, "variant_id": { "description": "ClinVar variant ID (e.g., '12345') At least one of gene, condition, or variant_id must be provided.", "type": "string" } }, "required": [], "type": "object" }