Cortexa research tool·structure·dose_response

DoseResponse Compare Potency

Quantify relative potency between two compounds by independently fitting Hill sigmoidal curves to each concentration-response dataset and computing the EC50 fold-shift (compound B EC50 / compound A EC50). Reports EC50, Hill exponent, and plateau Emax per compound, the potency fold-ratio, and which compound is more potent. Applications include lead optimisation, matched-pair structure-activity analysis, and selectivity profiling.

Livelast probed 2026-04-30 23:07Z· 3684msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 3684ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "conc_a": {
      "description": "Concentrations for compound A",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "conc_b": {
      "description": "Concentrations for compound B",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "compare_potency"
      ],
      "type": "string"
    },
    "resp_a": {
      "description": "Responses for compound A",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "resp_b": {
      "description": "Responses for compound B",
      "items": {
        "type": "number"
      },
      "type": "array"
    }
  },
  "required": [
    "operation",
    "conc_a",
    "resp_a",
    "conc_b",
    "resp_b"
  ],
  "type": "object"
}

Examples (1)

Default DoseResponse Compare Potency call

public-safeinput

{
  "conc_a": [],
  "conc_b": [],
  "operation": "",
  "resp_a": [],
  "resp_b": []
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_DoseResponse_compare_potency
Tool name: DoseResponse_compare_potency
Added: 2026-04-30 22:47Z
Tags: tooluniverse

DoseResponse Compare Potency

Livelast probed 2026-04-30 23:07Z· 3684msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "conc_a": { "description": "Concentrations for compound A", "items": { "type": "number" }, "type": "array" }, "conc_b": { "description": "Concentrations for compound B", "items": { "type": "number" }, "type": "array" }, "operation": { "description": "Operation type", "enum": [ "compare_potency" ], "type": "string" }, "resp_a": { "description": "Responses for compound A", "items": { "type": "number" }, "type": "array" }, "resp_b": { "description": "Responses for compound B", "items": { "type": "number" }, "type": "array" } }, "required": [ "operation", "conc_a", "resp_a", "conc_b", "resp_b" ], "type": "object" }