DoseResponse Fit Curve

Overview

Nonlinear regression of paired concentration-response measurements to the Hill sigmoidal (4PL) model: f(x) = Emin + (Emax - Emin) / (1 + (EC50/x)^n). Returns the four fitted parameters (baseline Emin, plateau Emax, midpoint EC50, Hill exponent n) with standard errors, 95% CI for EC50, coefficient of determination R2, and predicted response at each measured concentration. Requires at least 4 positive concentration inputs. Useful for characterising pharmacological potency and assessing assay data quality.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

2960ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "concentrations": {
      "description": "Drug concentrations (must be positive, e.g., [0.001, 0.01, 0.1, 1, 10, 100] in µM). At least 4 points required.",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "fit_curve"
      ],
      "type": "string"
    },
    "responses": {
      "description": "Observed responses at each concentration (e.g., % inhibition [0-100] or viability [0-100]). Same length as concentrations.",
      "items": {
        "type": "number"
      },
      "type": "array"
    }
  },
  "required": [
    "operation",
    "concentrations",
    "responses"
  ],
  "type": "object"
}

Examples (1)

{
  "concentrations": [],
  "operation": "",
  "responses": []
}

Identifiers

Catalog ID

tu_DoseResponse_fit_curve

Tool name

DoseResponse_fit_curve

Added

2026-05-01 00:58Z

Tags

tooluniverse