Cortexa research tool·drug discovery·drug_synergy

DrugSynergy Calculate Bliss

Calculate Bliss Independence synergy score for a drug combination. Model: E_expected = E_a + E_b - E_a*E_b. Synergy score = (E_combo - E_expected) * 100. Positive = synergy; Negative = antagonism. Inputs are fractional inhibition values (0-1). Based on Bliss (1939). Use for: single-concentration combination screening, high-throughput synergy assessment.

Livelast probed 2026-05-01 01:00Z· 2676msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 2676ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "effect_a": {
      "description": "Fractional inhibition of drug A alone (0=no effect, 1=complete inhibition)",
      "maximum": 1,
      "minimum": 0,
      "type": "number"
    },
    "effect_b": {
      "description": "Fractional inhibition of drug B alone (0=no effect, 1=complete inhibition)",
      "maximum": 1,
      "minimum": 0,
      "type": "number"
    },
    "effect_combination": {
      "description": "Observed fractional inhibition of the drug combination",
      "maximum": 1,
      "minimum": 0,
      "type": "number"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "calculate_bliss"
      ],
      "type": "string"
    }
  },
  "required": [
    "operation",
    "effect_a",
    "effect_b",
    "effect_combination"
  ],
  "type": "object"
}

Examples (1)

Default DrugSynergy Calculate Bliss call

public-safeinput

{
  "effect_a": 1,
  "effect_b": 1,
  "effect_combination": 1,
  "operation": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_DrugSynergy_calculate_bliss
Tool name: DrugSynergy_calculate_bliss
Added: 2026-05-01 00:58Z
Tags: tooluniverse

DrugSynergy Calculate Bliss

Livelast probed 2026-05-01 01:00Z· 2676msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "effect_a": { "description": "Fractional inhibition of drug A alone (0=no effect, 1=complete inhibition)", "maximum": 1, "minimum": 0, "type": "number" }, "effect_b": { "description": "Fractional inhibition of drug B alone (0=no effect, 1=complete inhibition)", "maximum": 1, "minimum": 0, "type": "number" }, "effect_combination": { "description": "Observed fractional inhibition of the drug combination", "maximum": 1, "minimum": 0, "type": "number" }, "operation": { "description": "Operation type", "enum": [ "calculate_bliss" ], "type": "string" } }, "required": [ "operation", "effect_a", "effect_b", "effect_combination" ], "type": "object" }