DrugSynergy Calculate Ci

Overview

Calculate Chou-Talalay Combination Index (CI) for drug synergy quantification. CI is derived from the Median Effect Equation: fa/fu = (D/Dm)^m. CI < 1 indicates synergy, CI = 1 is additive, CI > 1 is antagonism. Also computes the Dose Reduction Index (DRI) showing how much each drug dose can be reduced in combination. Supports both mutually exclusive (drugs with similar mechanisms) and mutually non-exclusive (drugs with different mechanisms) assumptions. Based on Chou & Talalay (1984). Use for: quantitative synergy assessment, dose optimization, isobologram analysis.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

142ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "assumption": {
      "description": "Whether drugs have similar (mutually_exclusive) or different (mutually_non_exclusive) mechanisms of action. Default: mutually_exclusive",
      "enum": [
        "mutually_exclusive",
        "mutually_non_exclusive"
      ],
      "type": "string"
    },
    "dose_a_combo": {
      "description": "Dose of drug A used in the combination",
      "type": "number"
    },
    "dose_b_combo": {
      "description": "Dose of drug B used in the combination",
      "type": "number"
    },
    "doses_a_single": {
      "description": "Concentration values for drug A single-agent dose-response (e.g., [0.01, 0.1, 1, 10, 100])",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "doses_b_single": {
      "description": "Concentration values for drug B single-agent dose-response",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "effect_combo": {
      "description": "Observed fractional inhibition of the combination (0-1 scale, must be between 0 and 1 exclusive)",
      "type": "number"
    },
    "effects_a_single": {
      "description": "Fractional inhibition of drug A alone at each dose (0-1 scale)",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "effects_b_single": {
      "description": "Fractional inhibition of drug B alone at each dose (0-1 scale)",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "calculate_ci"
      ],
      "type": "string"
    }
  },
  "required": [
    "operation",
    "doses_a_single",
    "effects_a_single",
    "doses_b_single",
    "effects_b_single",
    "dose_a_combo",
    "dose_b_combo",
    "effect_combo"
  ],
  "type": "object"
}

Examples (1)

{
  "dose_a_combo": 1,
  "dose_b_combo": 1,
  "doses_a_single": [],
  "doses_b_single": [],
  "effect_combo": 1,
  "effects_a_single": [],
  "effects_b_single": [],
  "operation": ""
}

Identifiers

Catalog ID

tu_DrugSynergy_calculate_ci

Tool name

DrugSynergy_calculate_ci

Added

2026-05-01 00:58Z

Tags

tooluniverse