Cortexa research tool·drug discovery·drug_synergy

DrugSynergy Calculate Hsa

Calculate Highest Single Agent (HSA) synergy score for drug combinations across dose points. HSA expected = max(E_a, E_b) at each dose. Synergy = observed - HSA expected. Requires matching arrays of effects for drug A, drug B, and the combination. Use for: multi-dose combination matrices, identifying synergistic dose ranges.

Livelast probed 2026-05-01 01:00Z· 101msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 101ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "effects_a": {
      "description": "Array of drug A inhibition effects at each dose point (0-1 or 0-100)",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "effects_b": {
      "description": "Array of drug B inhibition effects at each dose point (same length as effects_a)",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "effects_combo": {
      "description": "Array of combination inhibition effects at each dose point (same length as effects_a)",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "calculate_hsa"
      ],
      "type": "string"
    }
  },
  "required": [
    "operation",
    "effects_a",
    "effects_b",
    "effects_combo"
  ],
  "type": "object"
}

Examples (1)

Default DrugSynergy Calculate Hsa call

public-safeinput

{
  "effects_a": [],
  "effects_b": [],
  "effects_combo": [],
  "operation": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_DrugSynergy_calculate_hsa
Tool name: DrugSynergy_calculate_hsa
Added: 2026-05-01 00:58Z
Tags: tooluniverse

DrugSynergy Calculate Hsa

Livelast probed 2026-05-01 01:00Z· 101msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "effects_a": { "description": "Array of drug A inhibition effects at each dose point (0-1 or 0-100)", "items": { "type": "number" }, "type": "array" }, "effects_b": { "description": "Array of drug B inhibition effects at each dose point (same length as effects_a)", "items": { "type": "number" }, "type": "array" }, "effects_combo": { "description": "Array of combination inhibition effects at each dose point (same length as effects_a)", "items": { "type": "number" }, "type": "array" }, "operation": { "description": "Operation type", "enum": [ "calculate_hsa" ], "type": "string" } }, "required": [ "operation", "effects_a", "effects_b", "effects_combo" ], "type": "object" }