DrugSynergy Calculate Loewe

Overview

Calculate Loewe Additivity synergy score for a drug combination. The Loewe model is the most widely used reference model for drug interaction: d_a/D_a(E) + d_b/D_b(E) = 1 at additivity. If sum < 1, the combination is synergistic (needs less drug than expected); if > 1, it is antagonistic. Requires single-agent dose-response data for each drug (to fit Hill curves) plus the combination doses and observed effect. Based on Loewe & Muischnek (1926). Use for: rigorous synergy quantification with dose-response data, comparison with Bliss/HSA/ZIP models.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

97ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "dose_a_combo": {
      "description": "Dose of drug A used in the combination",
      "type": "number"
    },
    "dose_b_combo": {
      "description": "Dose of drug B used in the combination",
      "type": "number"
    },
    "doses_a_single": {
      "description": "Concentration values for drug A single-agent dose-response (e.g., [0.01, 0.1, 1, 10, 100])",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "doses_b_single": {
      "description": "Concentration values for drug B single-agent dose-response",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "effect_combo": {
      "description": "Observed fractional inhibition of the combination (0-1 scale)",
      "type": "number"
    },
    "effects_a_single": {
      "description": "Fractional inhibition of drug A alone at each dose (0-1 scale, same length as doses_a_single)",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "effects_b_single": {
      "description": "Fractional inhibition of drug B alone at each dose (0-1 scale, same length as doses_b_single)",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "calculate_loewe"
      ],
      "type": "string"
    }
  },
  "required": [
    "operation",
    "doses_a_single",
    "effects_a_single",
    "doses_b_single",
    "effects_b_single",
    "dose_a_combo",
    "dose_b_combo",
    "effect_combo"
  ],
  "type": "object"
}

Examples (1)

{
  "dose_a_combo": 1,
  "dose_b_combo": 1,
  "doses_a_single": [],
  "doses_b_single": [],
  "effect_combo": 1,
  "effects_a_single": [],
  "effects_b_single": [],
  "operation": ""
}

Identifiers

Catalog ID

tu_DrugSynergy_calculate_loewe

Tool name

DrugSynergy_calculate_loewe

Added

2026-04-30 22:47Z

Tags

tooluniverse