DrugSynergy Calculate Zip

Overview

Calculate ZIP (Zero Interaction Potency) delta synergy score from a full dose-response matrix. Fits Hill curves to marginal dose-response data for each drug and calculates expected additivity. Returns delta matrix where positive values indicate synergy. Based on Yadav et al. (2015). IMPORTANT: Each drug must have ≥3 non-zero dose points with measurable inhibition for Hill curve fitting to succeed. A 3×3 matrix with non-zero doses_a and doses_b (no zero-dose rows/columns) is the minimum; 4×4 or larger matrices are recommended. If Hill fitting fails, use calculate_bliss instead. Interpretation: score > 10 = Synergy, -10 to 10 = Additivity, < -10 = Antagonism. Use for: comprehensive combination screening matrices.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

3157ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "doses_a": {
      "description": "Concentration values for drug A (e.g., [0.01, 0.1, 1, 10])",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "doses_b": {
      "description": "Concentration values for drug B (e.g., [0.01, 0.1, 1, 10])",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "calculate_zip"
      ],
      "type": "string"
    },
    "viability_matrix": {
      "description": "2D matrix of cell viability percentages (0-100). Rows = doses_a, Columns = doses_b.",
      "items": {
        "items": {
          "type": "number"
        },
        "type": "array"
      },
      "type": "array"
    }
  },
  "required": [
    "operation",
    "doses_a",
    "doses_b",
    "viability_matrix"
  ],
  "type": "object"
}

Examples (1)

{
  "doses_a": [],
  "doses_b": [],
  "operation": "",
  "viability_matrix": []
}

Identifiers

Catalog ID

tu_DrugSynergy_calculate_zip

Tool name

DrugSynergy_calculate_zip

Added

2026-04-30 22:47Z

Tags

tooluniverse