DrugSynergy Calculate Zip
Calculate ZIP (Zero Interaction Potency) delta synergy score from a full dose-response matrix. Fits Hill curves to marginal dose-response data for each drug and calculates expected additivity. Returns delta matrix where positive values indicate synergy. Based on Yadav et al. (2015). IMPORTANT: Each drug must have ≥3 non-zero dose points with measurable inhibition for Hill curve fitting to succeed. A 3×3 matrix with non-zero doses_a and doses_b (no zero-dose rows/columns) is the minimum; 4×4 or…
Overview
Calculate ZIP (Zero Interaction Potency) delta synergy score from a full dose-response matrix. Fits Hill curves to marginal dose-response data for each drug and calculates expected additivity. Returns delta matrix where positive values indicate synergy. Based on Yadav et al. (2015). IMPORTANT: Each drug must have ≥3 non-zero dose points with measurable inhibition for Hill curve fitting to succeed. A 3×3 matrix with non-zero doses_a and doses_b (no zero-dose rows/columns) is the minimum; 4×4 or larger matrices are recommended. If Hill fitting fails, use calculate_bliss instead. Interpretation: score > 10 = Synergy, -10 to 10 = Additivity, < -10 = Antagonism. Use for: comprehensive combination screening matrices.
Schema
JSON Schema the agent (or your API call) must match.
Examples (1)
Default DrugSynergy Calculate Zip call
Anonymous-safe example. Rate-limited; no sign-in required.
Identifiers
- Catalog ID
- tu_DrugSynergy_calculate_zip
- Tool name
- DrugSynergy_calculate_zip
- Added
- 2026-04-30 22:47Z
- Tags
- tooluniverse