DynaMut2 Predict Stability
Predict the effect of a single-point amino acid mutation on protein stability and dynamics using DynaMut2. Provide a PDB ID (4-character code from RCSB PDB), chain identifier, and mutation in the format WtPosNew (e.g., V1A means Valine at position 1 mutated to Alanine). Returns the predicted change in Gibbs free energy (ddG in kcal/mol): positive = stabilizing, negative = destabilizing. The tool downloads the PDB structure from RCSB and submits it to DynaMut2 for analysis. Computation typically…
Overview
Predict the effect of a single-point amino acid mutation on protein stability and dynamics using DynaMut2. Provide a PDB ID (4-character code from RCSB PDB), chain identifier, and mutation in the format WtPosNew (e.g., V1A means Valine at position 1 mutated to Alanine). Returns the predicted change in Gibbs free energy (ddG in kcal/mol): positive = stabilizing, negative = destabilizing. The tool downloads the PDB structure from RCSB and submits it to DynaMut2 for analysis. Computation typically takes 15-30 seconds. Based on Normal Mode Analysis and graph-based signatures.
Schema
JSON Schema the agent (or your API call) must match.
Examples (1)
Default DynaMut2 Predict Stability call
Anonymous-safe example. Rate-limited; no sign-in required.
Identifiers
- Catalog ID
- tu_DynaMut2_predict_stability
- Tool name
- DynaMut2_predict_stability
- Added
- 2026-04-30 22:47Z
- Tags
- tooluniverse