EnsemblReg Get Constrained Elements

Overview

Get evolutionarily constrained elements in a genomic region from the Ensembl Compara database. Constrained elements are regions under purifying selection across species, indicating functional importance. Higher scores indicate stronger conservation. Use this to identify regulatory regions, coding exons, or other functional elements that are preserved across evolution. Essential for prioritizing non-coding variants and understanding regulatory conservation. Example: TP53 locus (chr17:7661779-7687538) returns 20 constrained elements with conservation scores up to 47.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

84ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "region": {
      "description": "Genomic region in format 'chromosome:start-end'. Example: '17:7661779-7687538' for TP53, '7:140424943-140624564' for BRAF.",
      "type": "string"
    },
    "species": {
      "default": "homo_sapiens",
      "description": "Species name. Use 'homo_sapiens' for human. Default: 'homo_sapiens'.",
      "type": "string"
    }
  },
  "required": [
    "region"
  ],
  "type": "object"
}

Examples (1)

{
  "region": ""
}

Identifiers

Catalog ID

tu_EnsemblReg_get_constrained_elements

Tool name

EnsemblReg_get_constrained_elements

Added

2026-05-01 00:58Z

Tags

tooluniverse