Cortexa research tool·genomics·epigraphdb

EpiGraphDB Get Mendelian Randomization

Get Mendelian Randomization (MR) evidence for a causal relationship between an exposure trait and an outcome trait using IEU OpenGWAS data. Returns MR estimates (beta, SE, p-value) from multiple instruments/methods. Example: exposure='Body mass index', outcome='Coronary heart disease' returns causal effect estimates.

Livelast probed 2026-04-30 23:07Z· 115msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 115ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "exposure_trait": {
      "description": "GWAS trait name for the exposure (e.g., 'Body mass index', 'LDL cholesterol', 'Type 2 diabetes'). Use EpiGraphDB_search_opengwas to find exact trait names.",
      "type": "string"
    },
    "outcome_trait": {
      "description": "GWAS trait name for the outcome (e.g., 'Coronary heart disease', 'Stroke', 'Alzheimer disease'). Use EpiGraphDB_search_opengwas to find exact trait names.",
      "type": "string"
    },
    "pval_threshold": {
      "default": 0.00001,
      "description": "P-value threshold for instrument selection (default 1e-5).",
      "type": "number"
    }
  },
  "required": [
    "exposure_trait",
    "outcome_trait"
  ],
  "type": "object"
}

Examples (1)

Default EpiGraphDB Get Mendelian Randomization call

public-safeinput

{
  "exposure_trait": "type 2 diabetes",
  "outcome_trait": "type 2 diabetes",
  "pval_threshold": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_EpiGraphDB_get_mendelian_randomization
Tool name: EpiGraphDB_get_mendelian_randomization
Added: 2026-04-30 22:47Z
Tags: tooluniverse

EpiGraphDB Get Mendelian Randomization

Livelast probed 2026-04-30 23:07Z· 115msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "exposure_trait": { "description": "GWAS trait name for the exposure (e.g., 'Body mass index', 'LDL cholesterol', 'Type 2 diabetes'). Use EpiGraphDB_search_opengwas to find exact trait names.", "type": "string" }, "outcome_trait": { "description": "GWAS trait name for the outcome (e.g., 'Coronary heart disease', 'Stroke', 'Alzheimer disease'). Use EpiGraphDB_search_opengwas to find exact trait names.", "type": "string" }, "pval_threshold": { "default": 0.00001, "description": "P-value threshold for instrument selection (default 1e-5).", "type": "number" } }, "required": [ "exposure_trait", "outcome_trait" ], "type": "object" }