GtoPdb Get Interactions

Overview

Get pharmacological interactions between targets and ligands from the Guide to Pharmacology database. Provide gene_symbol (convenience, auto-resolves to targetId), targetId (from GtoPdb_search_targets), or ligandId (from GtoPdb_search_ligands) to filter interactions. Returns binding affinity (Ki, Kd, IC50, EC50), action type (agonist, antagonist, inhibitor, etc.), species, and assay information. NOTE: GtoPdb coverage focuses on GPCRs, ion channels, nuclear receptors, and enzymes; kinase inhibitors (EGFR, BRAF, ALK, VEGFR inhibitors) have limited interaction data — use ChEMBL_get_drug_mechanisms for those instead. No authentication required.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

7656ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "gene_symbol": {
      "description": "Gene symbol convenience parameter — automatically resolves to GtoPdb targetId. Works for gene-symbol-named targets (e.g., 'KRAS', 'EGFR', 'BRAF', 'ALK'). Traditional receptor names like 'DRD2' may not resolve; use GtoPdb_search_targets first to confirm. Prefer exact gene symbols over partial names.",
      "type": [
        "string",
        "null"
      ]
    },
    "ligandId": {
      "description": "GtoPdb ligand ID. Get from GtoPdb_search_ligands. Examples: 5765 (aspirin), 7093 (morphine)",
      "type": [
        "integer",
        "null"
      ]
    },
    "species": {
      "description": "Filter by species. Examples: 'Human', 'Mouse', 'Rat'",
      "type": [
        "string",
        "null"
      ]
    },
    "targetId": {
      "description": "GtoPdb target ID. Get from GtoPdb_search_targets. Examples: 2486 (dopamine beta-hydroxylase), 20 (5-HT1A receptor). Alias: target_id also accepted.",
      "type": [
        "integer",
        "null"
      ]
    },
    "target_id": {
      "description": "Alias for targetId. GtoPdb target ID.",
      "type": [
        "integer",
        "null"
      ]
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

{}

Identifiers

Catalog ID

tu_GtoPdb_get_interactions

Tool name

GtoPdb_get_interactions

Added

2026-04-30 22:47Z

Tags

tooluniverse