Cortexa research tool·structure·interpro_ext

InterPro Get Proteins By Domain

Find proteins that contain a specific InterPro domain. Performs a reverse lookup from an InterPro domain/family accession to the list of UniProt proteins annotated with that domain. Supports filtering by reviewed (Swiss-Prot) entries only. Useful for discovering all proteins in a protein family or containing a specific functional domain. Example: IPR011615 (p53 DNA-binding domain) returns 6,251 proteins including P04637 (TP53), P10276 (TP63), P63165 (TP73).

Livelast probed 2026-04-30 23:07Z· 126msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 126ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "domain_id": {
      "description": "InterPro accession ID. Examples: 'IPR011615' (p53 DNA-binding domain, 6K proteins), 'IPR000719' (Protein kinase domain, 2.2M proteins), 'IPR002117' (p53 family), 'IPR001245' (Serine-threonine/tyrosine-protein kinase).",
      "type": "string"
    },
    "page_size": {
      "default": 20,
      "description": "Number of proteins to return (1-50, default 20).",
      "type": "integer"
    },
    "reviewed_only": {
      "default": false,
      "description": "If true, only return Swiss-Prot reviewed entries (default false returns all UniProt).",
      "type": "boolean"
    }
  },
  "required": [
    "domain_id"
  ],
  "type": "object"
}

Examples (1)

Default InterPro Get Proteins By Domain call

public-safeinput

{
  "domain_id": "",
  "page_size": 1,
  "reviewed_only": false
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_InterPro_get_proteins_by_domain
Tool name: InterPro_get_proteins_by_domain
Added: 2026-04-30 22:47Z
Tags: tooluniverse

InterPro Get Proteins By Domain

Livelast probed 2026-04-30 23:07Z· 126msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "domain_id": { "description": "InterPro accession ID. Examples: 'IPR011615' (p53 DNA-binding domain, 6K proteins), 'IPR000719' (Protein kinase domain, 2.2M proteins), 'IPR002117' (p53 family), 'IPR001245' (Serine-threonine/tyrosine-protein kinase).", "type": "string" }, "page_size": { "default": 20, "description": "Number of proteins to return (1-50, default 20).", "type": "integer" }, "reviewed_only": { "default": false, "description": "If true, only return Swiss-Prot reviewed entries (default false returns all UniProt).", "type": "boolean" } }, "required": [ "domain_id" ], "type": "object" }