InterPro Get Residue Annotations
Get InterPro residue-level functional site annotations for a protein by UniProt accession. Returns specific residue positions for binding sites, active sites, conserved residues, and PTM/modified residues (e.g., from PIRSR, CDD member-database site rules) - distinct from domain/region architecture. The response is keyed by member-database signature accession; each entry has 'locations' with a 'description' (e.g., 'BINDING: ATP', 'ACT_SITE: Proton acceptor.') and 'fragments' listing the exact re…
Overview
Get InterPro residue-level functional site annotations for a protein by UniProt accession. Returns specific residue positions for binding sites, active sites, conserved residues, and PTM/modified residues (e.g., from PIRSR, CDD member-database site rules) - distinct from domain/region architecture. The response is keyed by member-database signature accession; each entry has 'locations' with a 'description' (e.g., 'BINDING: ATP', 'ACT_SITE: Proton acceptor.') and 'fragments' listing the exact residue start/end and the residue letter(s). Example: P00533 (EGFR) returns ~75 residue-site entries, e.g. PIRSR000617-2 BINDING ATP at K745 and R841, PIRSR638784-1 ACT_SITE Proton acceptor at D855. Use to pinpoint catalytic and ligand-contacting residues at single-residue resolution.
Schema
JSON Schema the agent (or your API call) must match.
Examples (1)
Default InterPro Get Residue Annotations call
Anonymous-safe example. Rate-limited; no sign-in required.
Identifiers
- Catalog ID
- tu_InterPro_get_residue_annotations
- Tool name
- InterPro_get_residue_annotations
- Added
- 2026-07-29 18:13Z
- Tags
- tooluniverse