L1000FWD Sig Search
Transcriptomic signature query against the LINCS L1000 Connectivity Map via the L1000FWD Fireworks REST API (maayanlab.cloud/L1000FWD). Accepts two gene sets representing transcriptional changes in a condition of interest: genes increasing and genes decreasing. Internally issues a POST to /sig_search to register the query, then fetches ranked hits from /result/topn/{result_id}. Each returned hit is an L1000 perturbation record containing sig_id, combined score, p-value, and q-value. mode='simil…
Overview
Transcriptomic signature query against the LINCS L1000 Connectivity Map via the L1000FWD Fireworks REST API (maayanlab.cloud/L1000FWD). Accepts two gene sets representing transcriptional changes in a condition of interest: genes increasing and genes decreasing. Internally issues a POST to /sig_search to register the query, then fetches ranked hits from /result/topn/{result_id}. Each returned hit is an L1000 perturbation record containing sig_id, combined score, p-value, and q-value. mode='similar' retrieves perturbations that activate the same transcriptional programme (e.g. disease mimics); mode='opposite' retrieves perturbations that invert it, the classical computational drug-repurposing approach. No authentication required.
Schema
JSON Schema the agent (or your API call) must match.
Examples (1)
Default L1000FWD Sig Search call
Anonymous-safe example. Rate-limited; no sign-in required.
Identifiers
- Catalog ID
- tu_L1000FWD_sig_search
- Tool name
- L1000FWD_sig_search
- Added
- 2026-04-30 22:47Z
- Tags
- tooluniverse