LINCS Search Signatures

Overview

Search LINCS (Library of Integrated Network-Based Cellular Signatures) for drug perturbation gene expression signatures. Find L1000 and other assay signatures by drug/compound name, optionally filtered by cell line. Returns signature IDs, doses, time points, tissue, disease context, and PubChem IDs. LINCS contains 1.5M+ signatures from 431+ libraries covering thousands of drugs across hundreds of cell lines. Example: searching 'vorinostat' returns HDAC inhibitor signatures across multiple cell lines and doses.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

91ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "cell_line": {
      "description": "Optional cell line filter. Examples: 'MCF7', 'A549', 'HepG2', 'PC3'. Leave empty to search all cell lines.",
      "type": "string"
    },
    "drug_name": {
      "description": "Drug or perturbagen name to search for. Case-sensitive, use lowercase for best results. Examples: 'vorinostat', 'imatinib', 'dexamethasone', 'trichostatin-a'.",
      "type": "string"
    },
    "limit": {
      "description": "Maximum number of signatures to return (1-100). Default: 20.",
      "type": "integer"
    }
  },
  "required": [
    "drug_name"
  ],
  "type": "object"
}

Examples (1)

{
  "drug_name": "",
  "limit": 3
}

Identifiers

Catalog ID

tu_LINCS_search_signatures

Tool name

LINCS_search_signatures

Added

2026-04-30 22:47Z

Tags

tooluniverse