Cortexa research tool·genomics·mutalyzer

Mutalyzer Back Translate

Convert a protein-level HGVS variant to possible DNA-level variant descriptions using Mutalyzer. Given a protein change like NP_002993.1:p.Asp92Tyr, returns the corresponding coding DNA change(s) like NM_003002.4:c.(274G>T). Useful for finding the DNA-level representation of a known amino acid change, accounting for codon degeneracy.

Livelast probed 2026-05-01 01:00Z· 105msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 105ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "variant": {
      "description": "Protein-level HGVS variant description. Examples: 'NP_002993.1:p.Asp92Tyr' (SDHD), 'NP_000537.3:p.Pro72Arg' (TP53), 'NP_000050.2:p.Tyr32Cys' (BRCA2). Format: NP_accession:p.AminoAcidChange",
      "type": "string"
    }
  },
  "required": [
    "variant"
  ],
  "type": "object"
}

Examples (1)

Default Mutalyzer Back Translate call

public-safeinput

{
  "variant": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_Mutalyzer_back_translate
Tool name: Mutalyzer_back_translate
Added: 2026-05-01 00:58Z
Tags: tooluniverse

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