Cortexa research tool·drug discovery·nca

NCA Calculate Bioavailability

Calculate absolute oral bioavailability (F) from paired IV and PO pharmacokinetic study AUC values and doses. Formula: F = (AUC_PO × Dose_IV) / (AUC_IV × Dose_PO). Classifies result as High (≥80%), Moderate (30–80%), Low (10–30%), or Very Low (<10%) with clinical interpretation. F > 20% is typically considered acceptable for small molecule oral drugs. F ≥ 80% required for bioequivalence. Use after NCA_compute_parameters to calculate AUC from raw time-concentration data for both IV and PO arms.

Livelast probed 2026-05-01 01:00Z· 101msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 101ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "auc_iv": {
      "description": "AUC from the intravenous (IV) arm. Example: 3500 (ng/mL·h).",
      "type": "number"
    },
    "auc_po": {
      "description": "AUC from the oral (PO) arm. Must be in same units as auc_iv. Example: 2400 (ng/mL·h).",
      "type": "number"
    },
    "dose_iv": {
      "description": "Dose administered intravenously. Example: 50 (mg).",
      "type": "number"
    },
    "dose_po": {
      "description": "Dose administered orally. Must be in same units as dose_iv. Example: 100 (mg).",
      "type": "number"
    }
  },
  "required": [
    "auc_po",
    "dose_po",
    "auc_iv",
    "dose_iv"
  ],
  "type": "object"
}

Examples (1)

Default NCA Calculate Bioavailability call

public-safeinput

{
  "auc_iv": 1,
  "auc_po": 1,
  "dose_iv": 1,
  "dose_po": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_NCA_calculate_bioavailability
Tool name: NCA_calculate_bioavailability
Added: 2026-05-01 00:58Z
Tags: tooluniverse

NCA Calculate Bioavailability

Livelast probed 2026-05-01 01:00Z· 101msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "auc_iv": { "description": "AUC from the intravenous (IV) arm. Example: 3500 (ng/mL·h).", "type": "number" }, "auc_po": { "description": "AUC from the oral (PO) arm. Must be in same units as auc_iv. Example: 2400 (ng/mL·h).", "type": "number" }, "dose_iv": { "description": "Dose administered intravenously. Example: 50 (mg).", "type": "number" }, "dose_po": { "description": "Dose administered orally. Must be in same units as dose_iv. Example: 100 (mg).", "type": "number" } }, "required": [ "auc_po", "dose_po", "auc_iv", "dose_iv" ], "type": "object" }