NCA Calculate Bioavailability

Calculate absolute oral bioavailability (F) from paired IV and PO pharmacokinetic study AUC values and doses. Formula: F = (AUC_PO × Dose_IV) / (AUC_IV × Dose_PO). Classifies result as High (≥80%), Moderate (30–80%), Low (10–30%), or Very Low (<10%) with clinical interpretation. F > 20% is typically considered acceptable for small molecule oral drugs. F ≥ 80% required for bioequivalence. Use after NCA_compute_parameters to calculate AUC from raw time-concentration data for both IV and PO arms.