NCA Compute Parameters

Overview

Perform Non-Compartmental Analysis (NCA) on time-concentration pharmacokinetic data. Computes key PK parameters: Cmax (peak concentration), Tmax (time to peak), AUC0-t (area under curve to last measured point using linear-log trapezoidal method), AUC0-inf (extrapolated), terminal elimination half-life (t½), elimination rate constant (λz), clearance (CL), and volume of distribution (Vd) when dose is provided. Follows FDA/EMA NCA guidelines. Use this when you have raw plasma concentration vs. time data from a PK study. Output includes goodness of AUC extrapolation assessment.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

1733ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "conc_unit": {
      "description": "Unit of concentration (default: 'ng/mL'). Examples: 'ng/mL', 'ug/L', 'nM'.",
      "type": [
        "string",
        "null"
      ]
    },
    "concentrations": {
      "description": "Plasma concentrations at each time point (same length as times). Example: [0, 150, 280, 220, 180, 120, 60, 30, 8].",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "dose": {
      "description": "Administered dose (optional). Required to calculate CL and Vd. Example: 100 (for 100 mg dose).",
      "type": [
        "number",
        "null"
      ]
    },
    "dose_unit": {
      "description": "Unit of dose (default: 'mg'). Examples: 'mg', 'ug', 'nmol'.",
      "type": [
        "string",
        "null"
      ]
    },
    "route": {
      "description": "Route of administration: 'iv' (default) or 'po'. Affects Vd calculation formula.",
      "type": [
        "string",
        "null"
      ]
    },
    "time_unit": {
      "description": "Unit of time (default: 'h'). Examples: 'h', 'min', 'd'.",
      "type": [
        "string",
        "null"
      ]
    },
    "times": {
      "description": "Time points in consistent units (hours recommended). Example: [0, 0.25, 0.5, 1, 2, 4, 8, 12, 24].",
      "items": {
        "type": "number"
      },
      "type": "array"
    }
  },
  "required": [
    "times",
    "concentrations"
  ],
  "type": "object"
}

Examples (1)

{
  "concentrations": [],
  "times": []
}

Identifiers

Catalog ID

tu_NCA_compute_parameters

Tool name

NCA_compute_parameters

Added

2026-04-30 22:47Z

Tags

tooluniverse