NCA Fit One Compartment

Overview

Fit a one-compartment IV bolus pharmacokinetic model (C(t) = C0 × exp(-k_el × t)) to plasma concentration-time data using nonlinear least squares. Returns C0 (initial concentration), k_el (elimination rate constant), t½ (half-life), R², and when dose is provided: Vd (volume of distribution) and CL (clearance). Assumes mono-exponential decline — appropriate for drugs with rapid distribution and linear elimination. If R² < 0.85, consider a two-compartment model. Use NCA_compute_parameters for model-independent analysis.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

92ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "conc_unit": {
      "description": "Unit of concentration (default: 'ng/mL').",
      "type": [
        "string",
        "null"
      ]
    },
    "concentrations": {
      "description": "Plasma concentrations at each time point. Example: [500, 380, 290, 170, 60, 8, 1.1, 0.1].",
      "items": {
        "type": "number"
      },
      "type": "array"
    },
    "dose": {
      "description": "Administered IV dose. Required to calculate Vd and CL.",
      "type": [
        "number",
        "null"
      ]
    },
    "dose_unit": {
      "description": "Unit of dose (default: 'mg').",
      "type": [
        "string",
        "null"
      ]
    },
    "time_unit": {
      "description": "Unit of time (default: 'h').",
      "type": [
        "string",
        "null"
      ]
    },
    "times": {
      "description": "Time points after IV administration. Example: [0, 0.5, 1, 2, 4, 8, 12, 24].",
      "items": {
        "type": "number"
      },
      "type": "array"
    }
  },
  "required": [
    "times",
    "concentrations"
  ],
  "type": "object"
}

Examples (1)

{
  "concentrations": [],
  "times": []
}

Identifiers

Catalog ID

tu_NCA_fit_one_compartment

Tool name

NCA_fit_one_compartment

Added

2026-05-01 00:58Z

Tags

tooluniverse