NCA Fit One Compartment
Fit a one-compartment IV bolus pharmacokinetic model (C(t) = C0 × exp(-k_el × t)) to plasma concentration-time data using nonlinear least squares. Returns C0 (initial concentration), k_el (elimination rate constant), t½ (half-life), R², and when dose is provided: Vd (volume of distribution) and CL (clearance). Assumes mono-exponential decline — appropriate for drugs with rapid distribution and linear elimination. If R² < 0.85, consider a two-compartment model. Use NCA_compute_parameters for mod…
Overview
Fit a one-compartment IV bolus pharmacokinetic model (C(t) = C0 × exp(-k_el × t)) to plasma concentration-time data using nonlinear least squares. Returns C0 (initial concentration), k_el (elimination rate constant), t½ (half-life), R², and when dose is provided: Vd (volume of distribution) and CL (clearance). Assumes mono-exponential decline — appropriate for drugs with rapid distribution and linear elimination. If R² < 0.85, consider a two-compartment model. Use NCA_compute_parameters for model-independent analysis.
Schema
JSON Schema the agent (or your API call) must match.
Examples (1)
Default NCA Fit One Compartment call
Anonymous-safe example. Rate-limited; no sign-in required.
Identifiers
- Catalog ID
- tu_NCA_fit_one_compartment
- Tool name
- NCA_fit_one_compartment
- Added
- 2026-05-01 00:58Z
- Tags
- tooluniverse