Cortexa research tool·genomics·ncbi_variation

NCBIVariation Hgvs To Spdi

Convert an HGVS variant description to SPDI notation using NCBI Variation Services. Accepts any valid HGVS description (genomic g., coding c., or RNA r.) and returns the equivalent SPDI representation(s). Also validates the input HGVS expression. Useful for normalizing variant representations and converting between notation systems.

Livelast probed 2026-05-01 01:00Z· 103msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 103ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "hgvs": {
      "description": "HGVS variant description. Examples: 'NC_000001.11:g.230710048A>G' (genomic), 'NM_000059.4:c.68_69del' (coding deletion in BRCA2), 'NM_000546.6:c.215C>G' (TP53 Pro72Arg)",
      "type": "string"
    }
  },
  "required": [
    "hgvs"
  ],
  "type": "object"
}

Examples (1)

Default NCBIVariation Hgvs To Spdi call

public-safeinput

{
  "hgvs": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_NCBIVariation_hgvs_to_spdi
Tool name: NCBIVariation_hgvs_to_spdi
Added: 2026-05-01 00:58Z
Tags: tooluniverse

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