OmniPath Get Cell Communication Annotations

Overview

Get cell-cell communication annotations for proteins from databases like CellPhoneDB, CellChatDB, CellTalkDB, ICELLNET, and other curated resources integrated into OmniPath. Returns role classifications (ligand/receptor), signaling pathway assignments, categories (Secreted Signaling, Cell-Cell Contact, ECM-Receptor), and other cell communication metadata. Useful for understanding the functional context of proteins in intercellular signaling. Example: TGFB1 (P01137) is annotated as 'ligand' in CellChatDB pathway 'TGFb' category 'Secreted Signaling'; TGFBR2 (P37173) is annotated as 'receptor' in multiple pathways.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

116ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "databases": {
      "description": "Filter by annotation database(s), comma-separated. Cell communication databases: CellPhoneDB, CellChatDB, CellTalkDB, ICELLNET, iTALK, scConnect, Cellinker, connectomeDB2020, Ramilowski2015, Baccin2019, LRdb, HPMR. Other databases: HPA_tissue, UniProt_tissue, PanglaoDB, CellTypist, DGIdb, Guide2Pharma. Default: CellPhoneDB,CellChatDB.",
      "type": [
        "string",
        "null"
      ]
    },
    "genesymbols": {
      "description": "Whether to include gene symbols in output (default: true).",
      "type": [
        "boolean",
        "null"
      ]
    },
    "proteins": {
      "description": "UniProt accession(s) or gene symbol(s), comma-separated. Examples: 'P01137,P37173', 'TGFB1,EGFR', 'P00533'.",
      "type": "string"
    }
  },
  "required": [
    "proteins"
  ],
  "type": "object"
}

Examples (1)

{
  "proteins": ""
}

Identifiers

Catalog ID

tu_OmniPath_get_cell_communication_annotations

Tool name

OmniPath_get_cell_communication_annotations

Added

2026-04-30 22:47Z

Tags

tooluniverse