Cortexa research tool·genomics·omnipath

OmniPath Get Dorothea Regulon

Get the complete DoRothEA regulon for a transcription factor from OmniPath. Returns all target genes with mode of regulation (MoR: +1=activation, -1=repression), DoRothEA confidence levels, and source databases. Optionally filter by confidence levels (A, B, C). DoRothEA is the standard resource for TF activity estimation in tools like VIPER, decoupleR, and PROGENy. Use for: TF regulon retrieval for activity scoring, network analysis.

Livelast probed 2026-05-01 01:00Z· 488msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 488ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "confidence_levels": {
      "description": "Comma-separated DoRothEA confidence levels to include (e.g., 'A,B' for high confidence only). Options: A, B, C, D, E. Default: all levels.",
      "type": [
        "string",
        "null"
      ]
    },
    "tf_gene": {
      "description": "Transcription factor gene symbol (e.g., 'TP53', 'MYC', 'STAT3', 'NF2')",
      "type": "string"
    }
  },
  "required": [
    "tf_gene"
  ],
  "type": "object"
}

Examples (1)

Default OmniPath Get Dorothea Regulon call

public-safeinput

{
  "tf_gene": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_OmniPath_get_dorothea_regulon
Tool name: OmniPath_get_dorothea_regulon
Added: 2026-05-01 00:58Z
Tags: tooluniverse

Back to catalog