OmniPath Get Enzyme Substrate

Overview

Get enzyme-substrate (post-translational modification) interactions from OmniPath. Integrates data from PhosphoSite, phosphoELM, dbPTM, SIGNOR, HPRD, KEA, and other PTM databases. Returns kinase/phosphatase->substrate relationships with specific residue positions, modification types, and supporting evidence. Critical for understanding signaling cascades downstream of receptor activation (e.g., RTK->SRC->downstream phosphorylation targets). Example: SRC kinase (P12931) has 200+ substrates with phosphorylation sites; LCK (P06239) phosphorylates SOCS3 at Y204 and Y221.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

101ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "enzymes": {
      "description": "Gene symbol(s) or UniProt ID(s) for enzyme/kinase. Comma-separated for multiple. Examples: 'SRC', 'P12931', 'LCK,FYN'.",
      "type": [
        "string",
        "null"
      ]
    },
    "limit": {
      "description": "Maximum number of results to return.",
      "type": [
        "integer",
        "null"
      ]
    },
    "organisms": {
      "description": "NCBI taxonomy ID. Default: 9606 (human).",
      "type": [
        "integer",
        "null"
      ]
    },
    "substrates": {
      "description": "Gene symbol(s) or UniProt ID(s) for substrate. Examples: 'STAT3', 'P40763'.",
      "type": [
        "string",
        "null"
      ]
    },
    "types": {
      "description": "Modification type filter. Options include: phosphorylation, ubiquitination, acetylation, methylation, sumoylation, glycosylation. Default: all types.",
      "type": [
        "string",
        "null"
      ]
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

{}

Identifiers

Catalog ID

tu_OmniPath_get_enzyme_substrate

Tool name

OmniPath_get_enzyme_substrate

Added

2026-05-01 00:58Z

Tags

tooluniverse