OmniPath Get Intercell Roles

Overview

Get intercellular communication roles for proteins from OmniPath. Classifies proteins as ligands, receptors, transmembrane proteins, secreted factors, or extracellular matrix components based on evidence from 40+ databases. Returns functional categories (ligand/receptor/adhesion/transporter), locational annotations (secreted/transmembrane/peripheral), consensus scores, and supporting databases. Critical for identifying which genes act as senders vs receivers in cell-cell communication. Example: querying EGFR shows it is classified as 'receptor' by 10 databases with consensus_score 7, plasma_membrane_transmembrane=true; querying TGFB1 shows it is a 'ligand' (secreted=true, transmitter=true).

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

494ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "categories": {
      "description": "Filter by intercellular role category. Examples: 'ligand', 'receptor', 'adhesion', 'transporter', 'ecm', 'transmembrane'. Comma-separated for multiple.",
      "type": [
        "string",
        "null"
      ]
    },
    "limit": {
      "description": "Maximum number of results to return. Default: no limit.",
      "type": [
        "integer",
        "null"
      ]
    },
    "proteins": {
      "description": "Gene symbol(s) or UniProt ID(s), comma-separated. Examples: 'EGFR', 'TGFB1,PDCD1', 'P00533,P01137'.",
      "type": [
        "string",
        "null"
      ]
    },
    "receiver": {
      "description": "Filter for receiver proteins (true) or non-receivers (false).",
      "type": [
        "boolean",
        "null"
      ]
    },
    "scope": {
      "description": "Filter by annotation scope: 'generic' (general role) or 'specific' (cell-type specific). Default: all.",
      "type": [
        "string",
        "null"
      ]
    },
    "secreted": {
      "description": "Filter for secreted proteins (true) or non-secreted (false).",
      "type": [
        "boolean",
        "null"
      ]
    },
    "transmitter": {
      "description": "Filter for transmitter/sender proteins (true) or non-transmitters (false).",
      "type": [
        "boolean",
        "null"
      ]
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

{}

Identifiers

Catalog ID

tu_OmniPath_get_intercell_roles

Tool name

OmniPath_get_intercell_roles

Added

2026-04-30 22:47Z

Tags

tooluniverse