Cortexa research tool·genomics·omnipath

OmniPath Get Tf Target Interactions

Get transcription factor (TF) to target gene interactions from OmniPath DoRothEA and CollecTRI regulons. Returns directed TF-target pairs with mode of regulation (activation/repression), DoRothEA confidence levels (A-E), and supporting evidence. Query by TF gene symbol or target gene. Use for: TF activity inference, regulatory network construction, identifying TF targets for VIPER/decoupleR analysis.

Livelast probed 2026-04-30 23:07Z· 89msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 89ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "confidence_level": {
      "description": "DoRothEA confidence level filter: A=highest (1-2 sources), B=high (3+ sources), C=medium, D=low, E=lowest. A/B recommended for analysis.",
      "enum": [
        "A",
        "B",
        "C",
        "D",
        "E",
        null
      ],
      "type": [
        "string",
        "null"
      ]
    },
    "target_gene": {
      "description": "Target gene symbol to find regulating TFs (e.g., 'CDKN1A', 'BCL2'). Mutually exclusive with tf_gene or can be combined.",
      "type": [
        "string",
        "null"
      ]
    },
    "tf_gene": {
      "description": "Transcription factor gene symbol (e.g., 'TP53', 'MYC', 'STAT3'). Mutually exclusive with target_gene or can be combined.",
      "type": [
        "string",
        "null"
      ]
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default OmniPath Get Tf Target Interactions call

public-safeinput

{}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_OmniPath_get_tf_target_interactions
Tool name: OmniPath_get_tf_target_interactions
Added: 2026-04-30 22:47Z
Tags: tooluniverse

OmniPath Get Tf Target Interactions

Livelast probed 2026-04-30 23:07Z· 89msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "confidence_level": { "description": "DoRothEA confidence level filter: A=highest (1-2 sources), B=high (3+ sources), C=medium, D=low, E=lowest. A/B recommended for analysis.", "enum": [ "A", "B", "C", "D", "E", null ], "type": [ "string", "null" ] }, "target_gene": { "description": "Target gene symbol to find regulating TFs (e.g., 'CDKN1A', 'BCL2'). Mutually exclusive with tf_gene or can be combined.", "type": [ "string", "null" ] }, "tf_gene": { "description": "Transcription factor gene symbol (e.g., 'TP53', 'MYC', 'STAT3'). Mutually exclusive with target_gene or can be combined.", "type": [ "string", "null" ] } }, "required": [], "type": "object" }