Cortexa research tool·drug discovery·oncokb

OncoKB Annotate Mutations

Annotate a cancer mutation using OncoKB. Accepts query string like 'BRAF V600E' or separate gene/variant parameters. Returns oncogenicity, mutation effect, and FDA-approved therapies. Alias for OncoKB_annotate_variant with query-string parsing. Demo mode available for BRAF, TP53, ROS1.

Livelast probed 2026-04-30 23:07Z· 109msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 109ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "gene": {
      "description": "Gene symbol (e.g., BRAF, EGFR, TP53)",
      "type": "string"
    },
    "operation": {
      "const": "annotate_variant",
      "description": "Operation type (fixed: annotate_variant)",
      "type": "string"
    },
    "query": {
      "description": "Mutation query string, e.g. 'BRAF V600E' or 'EGFR T790M'. Gene and variant separated by space.",
      "type": "string"
    },
    "tumor_type": {
      "description": "Optional OncoTree tumor type code (e.g., MEL, LUAD)",
      "type": "string"
    },
    "variant": {
      "description": "Protein change (e.g., V600E, T790M)",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default OncoKB Annotate Mutations call

public-safeinput

{
  "gene": "BRCA1",
  "query": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_OncoKB_annotate_mutations
Tool name: OncoKB_annotate_mutations
Added: 2026-04-30 22:47Z
Tags: tooluniverse

OncoKB Annotate Mutations

Livelast probed 2026-04-30 23:07Z· 109msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "gene": { "description": "Gene symbol (e.g., BRAF, EGFR, TP53)", "type": "string" }, "operation": { "const": "annotate_variant", "description": "Operation type (fixed: annotate_variant)", "type": "string" }, "query": { "description": "Mutation query string, e.g. 'BRAF V600E' or 'EGFR T790M'. Gene and variant separated by space.", "type": "string" }, "tumor_type": { "description": "Optional OncoTree tumor type code (e.g., MEL, LUAD)", "type": "string" }, "variant": { "description": "Protein change (e.g., V600E, T790M)", "type": "string" } }, "required": [], "type": "object" }