Cortexa research tool·drug discovery·oncokb

OncoKB Annotate Variant

Annotate a cancer variant for oncogenic potential and treatment implications using OncoKB. Returns evidence level, oncogenicity, mutation effect, and FDA-approved therapies. Requires ONCOKB_API_TOKEN env var (demo mode available for BRAF, TP53, ROS1). Example: BRAF V600E in melanoma.

Livelast probed 2026-05-01 01:00Z· 109msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 109ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "alteration": {
      "description": "Alias for variant. Protein change notation (e.g., \"V600E\", \"T790M\", \"G12D\").",
      "type": "string"
    },
    "gene": {
      "description": "Gene symbol (e.g., BRAF, EGFR, TP53, KRAS)",
      "type": "string"
    },
    "gene_symbol": {
      "description": "Alias for gene. Gene symbol (e.g., BRAF, EGFR, TP53, KRAS).",
      "type": "string"
    },
    "operation": {
      "const": "annotate_variant",
      "description": "Operation type (fixed: annotate_variant)",
      "type": "string"
    },
    "tumor_type": {
      "description": "Optional OncoTree tumor type code (e.g., MEL for melanoma, LUAD for lung adenocarcinoma)",
      "type": "string"
    },
    "variant": {
      "description": "Variant notation - protein change (e.g., V600E, T790M, G12D)",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

Default OncoKB Annotate Variant call

public-safeinput

{
  "gene": "BRCA1",
  "gene_symbol": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_OncoKB_annotate_variant
Tool name: OncoKB_annotate_variant
Added: 2026-05-01 00:58Z
Tags: tooluniverse

OncoKB Annotate Variant

Livelast probed 2026-05-01 01:00Z· 109msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "alteration": { "description": "Alias for variant. Protein change notation (e.g., \"V600E\", \"T790M\", \"G12D\").", "type": "string" }, "gene": { "description": "Gene symbol (e.g., BRAF, EGFR, TP53, KRAS)", "type": "string" }, "gene_symbol": { "description": "Alias for gene. Gene symbol (e.g., BRAF, EGFR, TP53, KRAS).", "type": "string" }, "operation": { "const": "annotate_variant", "description": "Operation type (fixed: annotate_variant)", "type": "string" }, "tumor_type": { "description": "Optional OncoTree tumor type code (e.g., MEL for melanoma, LUAD for lung adenocarcinoma)", "type": "string" }, "variant": { "description": "Variant notation - protein change (e.g., V600E, T790M, G12D)", "type": "string" } }, "required": [], "type": "object" }