OpenTargets Get Target Depmap Essentiality

Retrieve DepMap CRISPR gene essentiality for a target by Ensembl gene ID. Returns the overall isEssential flag plus per-tissue essentiality: for each tissue, the cell-line screens with depmapId, cell line name, geneEffect (Chronos score; more negative = more essential, roughly < -0.5 = dependency), and the cell line's expression of the gene. Use to assess cancer cell-line dependency on a target.