OpenTargets Target Disease Evidence

Overview

Explore IntOGen somatic driver evidence for a target-disease association. IMPORTANT: IntOGen only covers somatic tumor driver mutations — this tool returns empty data ({}) for non-cancer diseases (e.g., type 2 diabetes, hypertension). Empty results are expected and normal when querying non-oncology phenotypes. For non-cancer diseases or to query other data sources, use OpenTargets_get_evidence_by_datasource instead. Accepts gene_symbol (e.g. 'TP53') and disease_name (e.g. 'Crohn disease') as alternatives to ensemblId/efoId — IDs are auto-resolved via OpenTargets search.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

538ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "disease_name": {
      "description": "Disease or phenotype name (e.g., 'Crohn disease', 'breast carcinoma'). Auto-resolved to efoId.",
      "type": "string"
    },
    "efoId": {
      "description": "EFO/MONDO disease ID (e.g., EFO_0000384). Alternative to disease_name.",
      "type": "string"
    },
    "ensemblId": {
      "description": "Ensembl gene ID (e.g., ENSG00000141510). Alternative to gene_symbol.",
      "type": "string"
    },
    "gene_symbol": {
      "description": "HGNC gene symbol (e.g., 'TP53', 'BRCA1'). Auto-resolved to ensemblId.",
      "type": "string"
    }
  },
  "required": [],
  "type": "object"
}

Examples (1)

{
  "disease_name": "type 2 diabetes",
  "gene_symbol": "BRCA1"
}

Identifiers

Catalog ID

tu_OpenTargets_target_disease_evidence

Tool name

OpenTargets_target_disease_evidence

Added

2026-04-30 22:47Z

Tags

tooluniverse