Cortexa research tool·genomics·panther

PANTHER Enrichment

Perform gene set enrichment (overrepresentation) analysis using PANTHER. Given a gene list, identifies statistically enriched GO terms, PANTHER pathways, Reactome pathways, or protein classes using Fisher's exact test with FDR correction. PANTHER is one of the most widely used tools for functional enrichment in bioinformatics. Example: gene list 'TP53,BRCA1,EGFR,KRAS,PTEN' enriched for GO biological_process returns 'regulation of mitotic cell cycle phase transition' (FDR=0.003).

Livelast probed 2026-04-30 23:07Z· 106msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 106ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "annotation_dataset": {
      "description": "Annotation dataset for enrichment. Options: 'GO:0008150' (biological_process, default), 'GO:0003674' (molecular_function), 'GO:0005575' (cellular_component), 'ANNOT_TYPE_ID_PANTHER_PATHWAY' (PANTHER pathway), 'ANNOT_TYPE_ID_REACTOME_PATHWAY' (Reactome pathway), 'ANNOT_TYPE_ID_PANTHER_PC' (protein class).",
      "type": [
        "string",
        "null"
      ]
    },
    "gene_list": {
      "description": "Comma-separated list of gene symbols, UniProt IDs, or Ensembl IDs. Example: 'TP53,BRCA1,EGFR,KRAS,PTEN,APC,RB1'.",
      "type": "string"
    },
    "organism": {
      "description": "NCBI taxonomy ID. Default: 9606 (human). Others: 10090 (mouse), 7227 (fly), 559292 (yeast).",
      "type": [
        "integer",
        "null"
      ]
    }
  },
  "required": [
    "gene_list"
  ],
  "type": "object"
}

Examples (1)

Default PANTHER Enrichment call

public-safeinput

{
  "gene_list": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_PANTHER_enrichment
Tool name: PANTHER_enrichment
Added: 2026-04-30 22:47Z
Tags: tooluniverse

PANTHER Enrichment

Livelast probed 2026-04-30 23:07Z· 106msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "annotation_dataset": { "description": "Annotation dataset for enrichment. Options: 'GO:0008150' (biological_process, default), 'GO:0003674' (molecular_function), 'GO:0005575' (cellular_component), 'ANNOT_TYPE_ID_PANTHER_PATHWAY' (PANTHER pathway), 'ANNOT_TYPE_ID_REACTOME_PATHWAY' (Reactome pathway), 'ANNOT_TYPE_ID_PANTHER_PC' (protein class).", "type": [ "string", "null" ] }, "gene_list": { "description": "Comma-separated list of gene symbols, UniProt IDs, or Ensembl IDs. Example: 'TP53,BRCA1,EGFR,KRAS,PTEN,APC,RB1'.", "type": "string" }, "organism": { "description": "NCBI taxonomy ID. Default: 9606 (human). Others: 10090 (mouse), 7227 (fly), 559292 (yeast).", "type": [ "integer", "null" ] } }, "required": [ "gene_list" ], "type": "object" }