Cortexa research tool·genomics·panther

PANTHER Ortholog

Find orthologs of a gene across species using PANTHER evolutionary classification. Returns the orthologous gene in a target species with its persistent ID, gene symbol, and ortholog type (LDO=Least Diverged Ortholog, O=ortholog, P=paralog, X=xenolog, LDX=least diverged xenolog). PANTHER classifies orthologs by evolutionary divergence across 144 fully sequenced genomes. Example: P04637 (human TP53) maps to Tp53 (mouse P02340) as LDO.

Livelast probed 2026-05-01 01:00Z· 1046msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 1046ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "gene_id": {
      "description": "Gene identifier - UniProt accession, Ensembl ID, or gene symbol. Examples: 'P04637' (TP53), 'P38398' (BRCA1).",
      "type": "string"
    },
    "organism": {
      "description": "Source organism NCBI taxonomy ID. Default: 9606 (human).",
      "type": [
        "integer",
        "null"
      ]
    },
    "ortholog_type": {
      "description": "Ortholog type filter. Options: 'LDO' (least diverged ortholog, default), 'O' (all orthologs), 'P' (paralogs), 'X' (xenologs), 'LDX' (least diverged xenolog), 'all' (all types).",
      "type": [
        "string",
        "null"
      ]
    },
    "target_organism": {
      "description": "Target organism NCBI taxonomy ID. Default: 10090 (mouse). Others: 10116 (rat), 7227 (fly), 6239 (worm).",
      "type": [
        "integer",
        "null"
      ]
    }
  },
  "required": [
    "gene_id"
  ],
  "type": "object"
}

Examples (1)

Default PANTHER Ortholog call

public-safeinput

{
  "gene_id": "BRCA1"
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_PANTHER_ortholog
Tool name: PANTHER_ortholog
Added: 2026-05-01 00:58Z
Tags: tooluniverse

PANTHER Ortholog

Livelast probed 2026-05-01 01:00Z· 1046msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "gene_id": { "description": "Gene identifier - UniProt accession, Ensembl ID, or gene symbol. Examples: 'P04637' (TP53), 'P38398' (BRCA1).", "type": "string" }, "organism": { "description": "Source organism NCBI taxonomy ID. Default: 9606 (human).", "type": [ "integer", "null" ] }, "ortholog_type": { "description": "Ortholog type filter. Options: 'LDO' (least diverged ortholog, default), 'O' (all orthologs), 'P' (paralogs), 'X' (xenologs), 'LDX' (least diverged xenolog), 'all' (all types).", "type": [ "string", "null" ] }, "target_organism": { "description": "Target organism NCBI taxonomy ID. Default: 10090 (mouse). Others: 10116 (rat), 7227 (fly), 6239 (worm).", "type": [ "integer", "null" ] } }, "required": [ "gene_id" ], "type": "object" }