Pfam Get Family Proteins

Overview

Get proteins containing a specific Pfam domain, optionally filtered by species. Returns protein accessions, names, gene names, lengths, organisms, and exact domain positions (start/end residues). Can filter to SwissProt-reviewed proteins only and/or specific species by NCBI taxonomy ID. For example, PF00001 (7tm_1 GPCR domain) has 289 human reviewed proteins including GPCRs like chemokine receptors, olfactory receptors, and serotonin receptors. PF00076 (RRM_1) has 199 human reviewed proteins. Use this to find which proteins in a species contain a specific domain.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

97ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "max_results": {
      "default": 20,
      "description": "Maximum number of proteins to return (default 20, max 100).",
      "type": "integer"
    },
    "pfam_accession": {
      "description": "Pfam family accession. Examples: 'PF00001' (7tm_1 GPCR), 'PF00076' (RRM_1), 'PF00069' (Pkinase), 'PF00125' (Core histone).",
      "type": "string"
    },
    "reviewed_only": {
      "default": true,
      "description": "If true (default), return only SwissProt-reviewed proteins. Set false for all UniProt proteins.",
      "type": "boolean"
    },
    "tax_id": {
      "description": "NCBI taxonomy ID to filter by species. Examples: '9606' (human), '10090' (mouse), '7227' (Drosophila), '559292' (S. cerevisiae).",
      "type": [
        "string",
        "null"
      ]
    }
  },
  "required": [
    "pfam_accession"
  ],
  "type": "object"
}

Examples (1)

{
  "max_results": 1,
  "pfam_accession": "P38398",
  "reviewed_only": false
}

Identifiers

Catalog ID

tu_Pfam_get_family_proteins

Tool name

Pfam_get_family_proteins

Added

2026-05-01 00:58Z

Tags

tooluniverse