Cortexa research tool·structure·popgen

PopGen Fst

Calculate simplified Weir-Cockerham Fst between two populations given allele frequencies and sample sizes. Fst quantifies genetic differentiation: <0.05 little, 0.05-0.15 moderate, 0.15-0.25 great, >0.25 very great differentiation. Useful for measuring population structure and divergence at individual loci.

Livelast probed 2026-05-01 01:00Z· 106msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 106ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "n1": {
      "description": "Sample size (number of individuals) for population 1",
      "type": "integer"
    },
    "n2": {
      "description": "Sample size (number of individuals) for population 2",
      "type": "integer"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "fst"
      ],
      "type": "string"
    },
    "p1": {
      "description": "Allele frequency in population 1 [0, 1]",
      "type": "number"
    },
    "p2": {
      "description": "Allele frequency in population 2 [0, 1]",
      "type": "number"
    }
  },
  "required": [
    "operation",
    "p1",
    "p2",
    "n1",
    "n2"
  ],
  "type": "object"
}

Examples (1)

Default PopGen Fst call

public-safeinput

{
  "n1": 1,
  "n2": 1,
  "operation": "",
  "p1": 1,
  "p2": 1
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_PopGen_fst
Tool name: PopGen_fst
Added: 2026-05-01 00:58Z
Tags: tooluniverse

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