Cortexa research tool·genomics·popgen

PopGen Hwe Test

Test Hardy-Weinberg equilibrium for a biallelic locus given observed genotype counts (AA, Aa, aa). Computes allele frequencies, expected genotype counts under HWE, chi-square statistic with 1 df, and p-value. Reports whether the locus is in HWE (p > 0.05) and, if not, whether heterozygote excess or deficit is observed. Useful for detecting selection, inbreeding, assortative mating, or genotyping error at individual loci.

Livelast probed 2026-04-30 23:07Z· 101msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 101ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "obs_AA": {
      "description": "Observed count of homozygous dominant (AA) genotypes",
      "type": "integer"
    },
    "obs_Aa": {
      "description": "Observed count of heterozygous (Aa) genotypes",
      "type": "integer"
    },
    "obs_aa": {
      "description": "Observed count of homozygous recessive (aa) genotypes",
      "type": "integer"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "hwe_test"
      ],
      "type": "string"
    }
  },
  "required": [
    "operation",
    "obs_AA",
    "obs_Aa",
    "obs_aa"
  ],
  "type": "object"
}

Examples (1)

Default PopGen Hwe Test call

public-safeinput

{
  "obs_AA": 1,
  "obs_Aa": 1,
  "obs_aa": 1,
  "operation": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_PopGen_hwe_test
Tool name: PopGen_hwe_test
Added: 2026-04-30 22:47Z
Tags: tooluniverse

PopGen Hwe Test

Livelast probed 2026-04-30 23:07Z· 101msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "obs_AA": { "description": "Observed count of homozygous dominant (AA) genotypes", "type": "integer" }, "obs_Aa": { "description": "Observed count of heterozygous (Aa) genotypes", "type": "integer" }, "obs_aa": { "description": "Observed count of homozygous recessive (aa) genotypes", "type": "integer" }, "operation": { "description": "Operation type", "enum": [ "hwe_test" ], "type": "string" } }, "required": [ "operation", "obs_AA", "obs_Aa", "obs_aa" ], "type": "object" }