Cortexa research tool·structure·protacdb

ProtacDB Search Protacs

Search PROTAC-DB 3.0 for PROTAC (Proteolysis Targeting Chimera) compounds. Filter by target protein and/or E3 ligase. Returns PROTAC structures with DC50, Dmax, SMILES, cell line, and pharmacological data. At least one of target or e3_ligase is required. Use for: finding PROTACs targeting BRD4, KRAS, AR; comparing CRBN vs VHL-based PROTACs.

Livelast probed 2026-04-30 23:07Z· 95msCortexa

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed: 1d ago
Last success: 1d ago
Last latency: 95ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "e3_ligase": {
      "description": "E3 ubiquitin ligase (e.g., 'CRBN', 'VHL', 'MDM2', 'XIAP'). At least one of target or e3_ligase required.",
      "type": [
        "string",
        "null"
      ]
    },
    "max_results": {
      "default": 50,
      "description": "Maximum number of compounds to return (default 50, max 100)",
      "type": "integer"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "search_protacs"
      ],
      "type": "string"
    },
    "target": {
      "description": "Target protein name or gene symbol (e.g., 'BRD4', 'KRAS', 'AR', 'BCL2'). At least one of target or e3_ligase required.",
      "type": [
        "string",
        "null"
      ]
    }
  },
  "required": [
    "operation"
  ],
  "type": "object"
}

Examples (1)

Default ProtacDB Search Protacs call

public-safeinput

{
  "max_results": 1,
  "operation": ""
}

Expected response keys: success

Anonymous-safe example. Rate-limited; no sign-in required.

Identifiers

Catalog ID: tu_ProtacDB_search_protacs
Tool name: ProtacDB_search_protacs
Added: 2026-04-30 22:47Z
Tags: tooluniverse

ProtacDB Search Protacs

Livelast probed 2026-04-30 23:07Z· 95msCortexa

Schema

JSON Schema the agent (or your API call) must match.

{ "properties": { "e3_ligase": { "description": "E3 ubiquitin ligase (e.g., 'CRBN', 'VHL', 'MDM2', 'XIAP'). At least one of target or e3_ligase required.", "type": [ "string", "null" ] }, "max_results": { "default": 50, "description": "Maximum number of compounds to return (default 50, max 100)", "type": "integer" }, "operation": { "description": "Operation type", "enum": [ "search_protacs" ], "type": "string" }, "target": { "description": "Target protein name or gene symbol (e.g., 'BRD4', 'KRAS', 'AR', 'BCL2'). At least one of target or e3_ligase required.", "type": [ "string", "null" ] } }, "required": [ "operation" ], "type": "object" }