ProteomicsDB Get Protein Expression

Overview

Get mass spectrometry-based protein expression data across human tissues, cell lines, and body fluids from ProteomicsDB. Given a UniProt accession (e.g., P04637 for TP53), returns quantitative expression values (log10 iBAQ or TOP3) for each biological source where the protein was detected. ProteomicsDB provides MS-based proteomics data complementary to antibody-based expression in HPA and cancer proteomics in PDC. Filter by tissue category (tissue, cell line, fluid) and calculation method (iBAQ, TOP3). Expression values are log10-transformed normalized intensities. Returns tissue name, group, category, and expression statistics per source.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

92ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "calculation_method": {
      "description": "Protein quantification method. iBAQ (intensity-Based Absolute Quantification) or TOP3 (sum of top 3 peptide intensities). Default: iBAQ.",
      "enum": [
        "iBAQ",
        "TOP3"
      ],
      "type": "string"
    },
    "operation": {
      "description": "Operation type",
      "enum": [
        "get_protein_expression"
      ],
      "type": "string"
    },
    "tissue_category": {
      "description": "Filter by biological source category. 'tissue' for normal tissues, 'cell line' for cell lines, 'fluid' for body fluids, 'all' for everything. Default: all.",
      "enum": [
        "tissue",
        "cell line",
        "cell_line",
        "fluid",
        "all"
      ],
      "type": "string"
    },
    "uniprot_id": {
      "description": "UniProt accession for the protein (e.g., 'P04637' for TP53, 'P00533' for EGFR, 'P01116' for KRAS)",
      "type": "string"
    }
  },
  "required": [
    "operation",
    "uniprot_id"
  ],
  "type": "object"
}

Examples (1)

{
  "operation": "",
  "uniprot_id": ""
}

Identifiers

Catalog ID

tu_ProteomicsDB_get_protein_expression

Tool name

ProteomicsDB_get_protein_expression

Added

2026-04-30 22:47Z

Tags

tooluniverse