ReactomeAnalysis Pathway Enrichment

Overview

Perform pathway overrepresentation (enrichment) analysis using the Reactome Analysis Service. Submit a list of gene symbols, UniProt IDs, or Ensembl IDs and identify which Reactome pathways are statistically enriched. Returns pathways ranked by p-value with FDR correction, entity counts, and reaction coverage. Supports projection to human pathways for cross-species analysis. Example: submitting TP53, BRCA1, CDH1, EGFR, KRAS returns 394 enriched pathways including 'Developmental Lineage of Mammary Gland Myoepithelial Cells' (p=3.94e-08) and 'Signaling by ERBB2 KD Mutants'.

Status

The most recent probe succeeded. Safe to call from the agent today.

Last probed

1d ago

Last success

1d ago

Last latency

94ms

Schema

JSON Schema the agent (or your API call) must match.

{
  "properties": {
    "identifiers": {
      "description": "Newline-separated list of gene/protein identifiers. Supports gene symbols (TP53, BRCA1), UniProt IDs (P04637, P38398), or Ensembl IDs. Example: 'TP53\\nBRCA1\\nCDH1\\nEGFR\\nKRAS'.",
      "type": "string"
    },
    "include_disease": {
      "description": "Include disease pathways in results (default true).",
      "type": [
        "boolean",
        "null"
      ]
    },
    "page_size": {
      "description": "Number of pathways to return (default 20, max 50).",
      "type": [
        "integer",
        "null"
      ]
    },
    "projection": {
      "description": "Project identifiers to human Reactome pathways for cross-species analysis (default true).",
      "type": [
        "boolean",
        "null"
      ]
    }
  },
  "required": [
    "identifiers"
  ],
  "type": "object"
}

Examples (1)

{
  "identifiers": ""
}

Identifiers

Catalog ID

tu_ReactomeAnalysis_pathway_enrichment

Tool name

ReactomeAnalysis_pathway_enrichment

Added

2026-04-30 22:47Z

Tags

tooluniverse